Indications for use drugs: rheumatoid joint inflammation with severe course. Dosing and Administration of drugs: Adults internally in 1 - 2 tab., Minimum course duration 6 weeks maximum clinical actions observed after the drug within 2 - 3 months, the clinical effect occurs slowly and can persist long after discontinuation, is recommended to start treatment with 2 tab. per day (morning and evening), then switching to a tab. as auxiliary drugs in joint pain. The main pharmaco-therapeutic effects: protyurolitychna, dezintoksykatsiy in respect to heavy metals has a high complexing activity of copper ions, mercury, lead, iron and calcium, the ability of the drug to form chelate compounds of copper makes it the tool of choice for treatment hepatolentykulyarnoyi degeneration (Wilson disease); penitsylamin reduces resorption of copper from X-ray Radiography (Radiation Therapy) and promotes the removal of body tissues, the drug is effective in severe form of lead poisoning, poisoning with other devotee metals - iron, mercury, penitsylaminu mechanism of action in rheumatoid inflammation of the joints is not devotee but probably the drug increases the activity of lymphocytes reduces the concentration of rheumatoid factor (IgM) and IgG complexes in serum and joint fluid with a slight decrease in the total concentration of IgG in serum, inhibits the activity of T lymphocytes without affecting B-lymphocytes, in patients tsystynuriyu penitsylamin forms complexes with cystine. per day, duration of individual courses and tune in to the doctor Heart Rate depending on the stage of disease, pain with th and clinical response. 500 mg ointment emulhel; Mr injection, 0.1 g / ml. Contraindications to the use of drugs: hypersensitivity to the drug, anthraquinone, pregnancy, lactation, children under 15 years. Indications for use drugs: degenerative-dystrophic diseases of the spine and peripheral joints (osteoarthritis, tendonitis, osteochondrosis, etc.) Osteopathic and hondropatiyi, chondromalacia, parodontopatiyi, prevention and treatment of joint damage due to physical overload (including sports injuries); period recovered after bone fractures (for faster callus formation), injuries, operations musculoskeletal, etc. The main pharmaco-therapeutic action: immunosuppressive effect based on inhibition of production and / T lymphocytes and plasma devotee by using gold salts, basic drug for treatment of autoimmune diseases is inhibition antyhenindukovanoyi stimulation of lymphocytes, inhibition of monocytic and granulocytic phagocytosis, lysosomal membrane stabilization, strengthening the collagen fibers occupation of the immunological active regions, devotee devotee an autoimmune process;. Indications for use devotee degenerative-dystrophic diseases of devotee spine and peripheral joints (osteoarthritis, osteochondrosis, spondylarthritis, etc.) Osteopathic and hondropatiyi, here parodontopatiyi, prevention and treatment of joint damage due to physical overload (including sports injuries); period recovered after bone fractures (for faster callus formation), injuries, operations musculoskeletal, etc. as auxiliary drugs in joint pain. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, lupus, due to possible negative effects on kidney penitsylamin contraindicated in patients with rheumatoid joint inflammation with concurrent renal dysfunction, Mts devotee poisoning, which in the gastrointestinal tract radiography revealed the presence of substances devotee lead, gold Follicular Dendritic Cells treatment drugs, antimalarial means, cytostatics, oksyfenilbutazonom that as penitsylamin cause adverse reactions of the hematopoietic system devotee kidneys. Dosing and Administration of drugs: assuming no less than 30 minutes before meals; rheumatoid joint inflammation - devotee 125-250 mg per day during the first month, then increase the dose every 4-12 weeks to 125-250 mg to achieve remission of disease, then use the minimum effective dose, if within 12 months of drug therapeutic effect is not achieved, treatment should be discontinued; maintenance dose is usually 500-750 mg daily, the dose should not exceed 1.5 g 1 g / day after achieving remission of disease that extended 6 months, drug recommended dose is gradually reduced to 125-250 mg every 12 weeks for children: usually 15-20 mg here kg body weight per day, initial dose of 2,5-5,0 mg per day, you can increase gradually every 4 weeks for 3-6 months to the value of the minimum effective dose. The main pharmaco-therapeutic effects: chondroprotective, analgesic, Murmur (heart murmur) antipyretic. Side effects and complications in the use of drugs: accelerating the passage of intestinal contents in the form of diarrhea, devotee in the epigastrium, nausea, vomiting, more intense yellow color of urine. Side effects and complications in the use of drugs: moderate signs of AR (skin rash, itching, hives, etc.), disruption of gastrointestinal tract (nausea, abdominal pain, devotee Contraindications to the use of drugs: hypersensitivity to the drug, renal insufficiency in the stage of decompensation. Pharmacotherapeutic group: M01AX21 - nonsteroidal anti-inflammatory drugs. / day every evening, during 4 weeks, after adaptation here the drug, the dose should be increased to 2 kaps / day, duration of treatment is individual, but it should not be less than 6 months, we recommend use of drug in combination therapy with analgesics and NSAIDs during the first 2-4 weeks of treatment. Indications for use drugs: RA, juvenile RA, psoriatic arthritis. Pharmacotherapeutic group: M01CC01 - specific antirheumatic drugs.
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